Giorgio Mainerio (c. 1530-1540 - May 3 or 4, 1582) was an Italian musician and composer. He was born in Parma between 1530 and 1540. His father was possibly of Scottish origin. This hypothesis is based on the fact that Giorgio in his signature used Mayner as family name. During his education he studied also music, but he did not start from the very beginning a musical career. In 1560, although a Presbyterian, he applied for the position as chaplain and altarista at the church of Santa Maria Annunziata in Udine.
In Udine Mainerio spent ten years (from 1560 to 1570) and there, thanks to his previous musical knowledge and to the lessons given to him by two local contrapuntists, Gabriele Martinengo (Maestro di cappella from 1562 to 1567) and Ippolito Chiamaterò (Maestro di cappella from 1567 to 1570), he started his musical career (which was surely more lucrative for him than the religious one). After the first three years in Udine he began to be interested in occultism (astrology, magic and necromancy) and there were rumours that -together with some women- he was attending night rites. The Inquisition in Aquileia started a preliminary investigation, pursuing a possible trial but, since no further evidence was found, the case was closed. Anyway, also after the end of his problems with the justice, Mainiero had more and more troubles with his colleagues of the Chapter of Udine and, applied for a position at the Patriarchal Basilica of Aquileia.
In 1578 he became Maestro di cappella at the church of Sanata Chiesa d'Aquilegia. During the last years of his life he had problems with his health, escaping often his duty as master of the church, in favour of travels to Venice, Ancona and thermal baths.