Born at the time of the Kingdom of Hanover as the paternal uncle of the later women's rights activist Helene Lange. Otto Heinrich Lange underwent his musical training first in Leipzig, then also in Hanover, the city of residence at the time.
After Otto Heinrich Lange had already joined the Hanoverian Artists' Association in 1854, King George V, who resided in Hanover, appointed the musician second conductor of the Royal Court and Church Choir, later the Hanoverian Cathedral Choir, also called the Hanoverian Castle Church Choir, in 1857. In 1866, the year of the annexation of the Kingdom of Hanover by Prussia, Otto Heinrich Lange initially rose to the position of First Conductor "on trial", and in the following year, 1867, he assumed this position on a permanent basis until his retirement in 1886.
During his tenure, Otto Heinrich Lange continuously increased the quality of the choir he directed, composing his own songs and arranging other choral works. In addition, Lange published several collections of folk songs.
Otto Heinrich Lange died in Hanover on his 66th birthday.
